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The CPK (Total) Test, also known as CK-NAC (Creatine Kinase - N-Acetyl Cysteine activated method), is a biochemical test that measures the total activity of Creatine Phosphokinase (CPK or CK) in the blood. CPK is an enzyme found primarily in the heart, brain, and skeletal muscles, and it plays a key role in energy metabolism within muscle cells.
Elevated levels of total CPK may indicate:
Heart muscle injury (e.g., myocardial infarction or heart attack)
Skeletal muscle damage (e.g., trauma, muscular dystrophy, intense exercise)
Neuromuscular disorders
Certain medications or toxins causing muscle breakdown (rhabdomyolysis)
The CK-NAC method is a standardized and highly sensitive technique used in automated analyzers to accurately measure CPK levels.
This test is helpful in:
Diagnosing and monitoring heart attacks
Assessing muscle diseases or inflammation
Evaluating causes of unexplained muscle pain or weakness