LIPOPROTEIN ASSOSIATED PHOSPHOLIPASE A2 (LP-PLA2) Detail

Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) is an enzyme primarily bound to low-density lipoprotein (LDL) particles in the blood. It plays a key role in the inflammatory process within blood vessel walls, contributing to the formation of atherosclerotic plaques.

The Lp-PLA2 test measures the concentration or activity of this enzyme to help evaluate the risk of cardiovascular events, especially in individuals with:

• Intermediate or high risk of heart disease,

• Metabolic syndrome,

• Family history of early cardiovascular disease, or

• Normal cholesterol levels but other risk factors.

Elevated levels of Lp-PLA2 are associated with:

• Plaque inflammation and instability,

• Higher risk of coronary heart disease (CHD),

• Increased risk of ischemic stroke and heart attack.