CORDIOLIPIN ANTIBODY(ACL)-IgM Detail

The Cardiolipin Antibody (ACL) – IgM test measures the level of IgM autoantibodies directed against cardiolipin, a phospholipid present in the membranes of cells and platelets. These antibodies are associated with Antiphospholipid Syndrome (APS), a condition that increases the risk of blood clots (venous or arterial) and pregnancy complications like recurrent miscarriage, stillbirth, and preeclampsia.

While IgG antibodies are considered more specific for APS, IgM antibodies may appear earlier in the disease or in some cases independently. Therefore, this test is often used in combination with ACL IgG and Beta-2 Glycoprotein I antibody tests to confirm the diagnosis.

A persistently elevated IgM level (measured 12 weeks apart) may support the diagnosis of APS, especially when clinical symptoms such as thrombosis or pregnancy loss are present.